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non small cell lung cancer cell line  (ATCC)


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    ATCC non small cell lung cancer cell line
    Non Small Cell Lung Cancer Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 931 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/non+small+cell+lung+cancer+nci+h23/NCI-H23/pm41957099-106-5-15
    Average 96 stars, based on 931 article reviews
    non small cell lung cancer cell line - by Bioz Stars, 2026-10
    96/100 stars

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    Article Title: Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs
    Article Snippet: ID :2410HT63 Report Date :June 3, 2025 Test Date :October 21, 2024 Log10 High Conc :-4.0 Panel Cell Name Hollow Fiber GI50 Breast Cancer HS 578T -6.85* Leukemia MOLT-4 -6.77* Non-Small Cell Lung Cancer NCI-H522 -6.69** Breast Cancer BT-549 -6.68* Renal Cancer RXF 393 -6.63* Leukemia SR -6.62* Leukemia HL-60(TB) -6.62* Renal Cancer UO-31 -6.60* Non-Small Cell Lung Cancer A549/ATCC -6.56* Breast Cancer MCF7 -6.56* Non-Small Cell Lung Cancer NCI-H23 -6.55** CNS Cancer SF-268 -6.54* Leukemia CCRF-CEM -6.53* Melanoma SK-MEL-5 -6.48* Renal Cancer TK-10 -6.47* Renal Cancer ACHN -6.47* Renal Cancer SN12C -6.46* Non-Small Cell Lung Cancer EKVX -6.46* CNS Cancer SF-539 -6.46* Non-Small Cell Lung Cancer NCI-H460 -6.45* CNS Cancer SF-295 -6.44** Renal Cancer 786-0 -6.44* Leukemia K-562 -6.44* Colon Cancer HCT-116 -6.43* Renal Cancer CAKI-1 -6.41* Renal Cancer A498 -6.41* Prostate Cancer PC-3 -6.40* Colon Cancer HT29 -6.39* Non-Small Cell Lung Cancer HOP-62 -6.39* Melanoma MDA-MB-435 -6.38** Ovarian Cancer OVCAR-3 -6.36** Ovarian Cancer OVCAR-8 -6.30* Ovarian Cancer SK-OV-3 -6.29* Melanoma MALME-3M -6.28* Ovarian Cancer NCI/ADR-RES -6.25* Ovarian Cancer IGROV1 -6.22* CNS Cancer U251 -6.20** Melanoma SK-MEL-2 -6.09* Colon Cancer SW-620 -5.99** Non-Small Cell Lung Cancer NCI-H322M -5.97* Ovarian Cancer OVCAR-4 -5.95* Colon Cancer HCT-15 -5.94* Melanoma UACC-62 -5.92** Melanoma UACC-257 -5.90* Melanoma M14 -5.88* Breast Cancer T-47D -5.85* CNS Cancer SNB-19 -5.85* Breast Cancer MDA-MB-468 -5.73* Colon Cancer KM12 -5.71* Colon Cancer COLO 205 -5.65** Breast Cancer MDA-MB-231/ATCC -5.47** Non-Small Cell Lung Cancer NCI-H226 -5.41* Ovarian Cancer OVCAR-5 -5.35** Melanoma SK-MEL-28 -4.78* 147 National Cancer Institute Developmental Therapeutics Program Waterfall Graph TGI NSC : D - 852077/1 Units :Molar SSPL :1D4F EXP. .. ID :2410HT63 Report Date :June 3, 2025 Test Date :October 21, 2024 Log10 High Conc : -4.0 Panel Cell Name Hollow Fiber TGI Leukemia MOLT-4 -6.50* Breast Cancer HS 578T -6.45* Leukemia HL-60(TB) -6.36* Non-Small Cell Lung Cancer NCI-H522 -6.31** Breast Cancer BT-549 -6.28* Leukemia SR -6.27* Renal Cancer RXF 393 -6.27* Renal Cancer UO-31 -6.20* Non-Small Cell Lung Cancer A549/ATCC -6.12* Non-Small Cell Lung Cancer NCI-H23 -6.05** Non-Small Cell Lung Cancer EKVX -6.04* Leukemia CCRF-CEM -6.03* Melanoma SK-MEL-5 -6.02* Leukemia K-562 -6.02* Renal Cancer SN12C -5.97* Non-Small Cell Lung Cancer NCI-H460 -5.95* CNS Cancer SF-295 -5.90** CNS Cancer SF-539 -5.86* Renal Cancer ACHN -5.86* Non-Small Cell Lung Cancer HOP-62 -5.85* Renal Cancer A498 -5.85* Ovarian Cancer OVCAR-3 -5.83** Melanoma MALME-3M -5.81* Renal Cancer 786-0 -5.79* Ovarian Cancer OVCAR-8 -5.77* Melanoma MDA-MB-435 -5.70** CNS Cancer U251 -5.68** Melanoma SK-MEL-2 -5.62* Ovarian Cancer NCI/ADR-RES -5.60* Melanoma UACC-62 -5.59** Breast Cancer MCF7 -5.59* Melanoma UACC-257 -5.55* Colon Cancer HCT-15 -5.48* Ovarian Cancer IGROV1 -5.47* Ovarian Cancer OVCAR-4 -5.47* Melanoma M14 -5.43* Breast Cancer MDA-MB-468 -5.41* Non-Small Cell Lung Cancer NCI-H322M -5.38* Prostate Cancer PC-3 -5.36* Breast Cancer T-47D -5.36* Colon Cancer SW-620 -5.33** Colon Cancer COLO 205 -5.31** CNS Cancer SNB-19 -5.22* Colon Cancer HT29 -5.20* Colon Cancer KM12 -5.20* Colon Cancer HCT-116 -4.97* Ovarian Cancer SK-OV-3 -4.94* Renal Cancer CAKI-1 -4.88* Renal Cancer TK-10 -4.86* CNS Cancer SF-268 -4.80* Non-Small Cell Lung Cancer NCI-H226 -4.77* Ovarian Cancer OVCAR-5 -4.71** Melanoma SK-MEL-28 -4.45* Non-Small Cell Lung Cancer HOP-92 -4.42* Breast Cancer MDA-MB-231/ATCC -4.00>* 148 National Cancer Institute Developmental Therapeutics Program Waterfall Graph LC50 NSC : D - 852077/1 Units :Molar SSPL :1D4F EXP. .. ID: 2407HT57 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Leukemia -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 CCRF-CEM HL-60(TB) K-562 MOLT-4 RPMI-8226 SR Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Non-Small Cell Lung Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 A549/ATCC EKVX HOP-62 HOP-92 NCI-H226 NCI-H23 NCI-H322M NCI-H460 NCI-H522 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Colon Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 COLO 205 HCC-2998 HCT-116 HCT-15 HT29 KM12 SW-620 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th CNS Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 SF-268 SF-295 SF-539 SNB-19 SNB-75 U251 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Melanoma -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 LOX IMVI MALME-3M M14 MDA-MB-435 SK-MEL-2 SK-MEL-28 SK-MEL-5 UACC-257 UACC-62 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Ovarian Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 IGROV1 OVCAR-3 OVCAR-4 OVCAR-5 OVCAR-8 NCI/ADR-RES SK-OV-3 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Renal Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 786-0 A498 ACHN CAKI-1 RXF 393 SN12C TK-10 UO-31 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Prostate Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 PC-3 DU-145 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Breast Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 MCF7 MDA-MB-231/ HS 578T BT-549 T-47D MDA-MB-468 151 National Cancer Institute Developmental Therapeutics Program Mean Graphs NSC : D - 852082/1 Units :Molar SSPL :1D4F EXP.

    Article Title: Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs
    Article Snippet: ID :2405HT49 Report Date :June 3, 2025 Test Date :May 6, 2024 Log10 High Conc :-4.0 Panel Cell Name Hollow Fiber GI50 Non-Small Cell Lung Cancer NCI-H522 -7.03** Leukemia MOLT-4 -6.81* Non-Small Cell Lung Cancer EKVX -6.77* Breast Cancer HS 578T -6.77* Leukemia SR -6.68* Leukemia HL-60(TB) -6.67* CNS Cancer SF-539 -6.66* CNS Cancer SF-268 -6.61* Breast Cancer BT-549 -6.60* Renal Cancer SN12C -6.58* Non-Small Cell Lung Cancer A549/ATCC -6.57* Non-Small Cell Lung Cancer NCI-H460 -6.57* Non-Small Cell Lung Cancer HOP-62 -6.57* Melanoma SK-MEL-5 -6.54* Prostate Cancer DU-145 -6.54* Renal Cancer UO-31 -6.54* CNS Cancer SNB-75 -6.52* Renal Cancer TK-10 -6.52* Non-Small Cell Lung Cancer NCI-H23 -6.50** Renal Cancer ACHN -6.47* CNS Cancer SF-295 -6.47** Leukemia K-562 -6.46* Ovarian Cancer OVCAR-3 -6.44** Leukemia CCRF-CEM -6.43* Renal Cancer 786-0 -6.43* Renal Cancer CAKI-1 -6.42* Renal Cancer A498 -6.42* Colon Cancer HCT-116 -6.41* Breast Cancer MCF7 -6.40* Prostate Cancer PC-3 -6.33* Ovarian Cancer SK-OV-3 -6.31* Melanoma LOX IMVI -6.30** Colon Cancer SW-620 -6.29** Ovarian Cancer NCI/ADR-RES -6.28* Colon Cancer HT29 -6.28* Melanoma MALME-3M -6.26* Melanoma SK-MEL-2 -6.24* Melanoma MDA-MB-435 -6.22** Melanoma M14 -6.21* CNS Cancer U251 -6.12** Ovarian Cancer OVCAR-4 -6.08* Ovarian Cancer OVCAR-8 -6.05* Melanoma UACC-62 -5.95** Colon Cancer HCT-15 -5.95* CNS Cancer SNB-19 -5.93* Leukemia RPMI-8226 -5.93* Melanoma UACC-257 -5.79* Colon Cancer KM12 -5.76* Melanoma SK-MEL-28 -5.69* Non-Small Cell Lung Cancer NCI-H322M -5.68* Ovarian Cancer IGROV1 -5.67* Colon Cancer COLO 205 -5.65** Breast Cancer T-47D -5.65* Breast Cancer MDA-MB-468 -5.60* Breast Cancer MDA-MB-231/ATCC -5.55** Non-Small Cell Lung Cancer NCI-H226 -5.24* Ovarian Cancer OVCAR-5 -4.00>* 140 National Cancer Institute Developmental Therapeutics Program Waterfall Graph TGI NSC : D - 852077/1 Units :Molar SSPL :1D4F EXP. .. ID :2405HT49 Report Date :June 3, 2025 Test Date :May 6, 2024 Log10 High Conc : -4.0 Panel Cell Name Hollow Fiber TGI Leukemia MOLT-4 -6.53* Non-Small Cell Lung Cancer NCI-H522 -6.48** Leukemia HL-60(TB) -6.44* Leukemia SR -6.40* Non-Small Cell Lung Cancer EKVX -6.36* Breast Cancer HS 578T -6.25* Breast Cancer BT-549 -6.19* Non-Small Cell Lung Cancer NCI-H460 -6.13* Renal Cancer UO-31 -6.13* Melanoma SK-MEL-5 -6.10* Renal Cancer TK-10 -6.09* CNS Cancer SF-539 -6.01* Leukemia CCRF-CEM -5.98* Non-Small Cell Lung Cancer HOP-62 -5.98* Leukemia K-562 -5.92* Non-Small Cell Lung Cancer NCI-H23 -5.91** Renal Cancer SN12C -5.90* Non-Small Cell Lung Cancer A549/ATCC -5.90* Melanoma MALME-3M -5.87* Renal Cancer A498 -5.86* Ovarian Cancer OVCAR-3 -5.84** Renal Cancer ACHN -5.83* CNS Cancer SF-295 -5.81** Renal Cancer 786-0 -5.80* Ovarian Cancer NCI/ADR-RES -5.69* Melanoma LOX IMVI -5.67** CNS Cancer U251 -5.67** Ovarian Cancer OVCAR-8 -5.66* Melanoma SK-MEL-2 -5.62* Breast Cancer MCF7 -5.62* Melanoma UACC-62 -5.61** Leukemia RPMI-8226 -5.57* Ovarian Cancer SK-OV-3 -5.55* Colon Cancer HCT-15 -5.55* Melanoma M14 -5.55* Ovarian Cancer OVCAR-4 -5.53* Melanoma MDA-MB-435 -5.49** Colon Cancer HCT-116 -5.48* Melanoma UACC-257 -5.47* Colon Cancer HCC-2998 -5.44* Colon Cancer COLO 205 -5.35** Prostate Cancer PC-3 -5.34* Breast Cancer MDA-MB-468 -5.32* Colon Cancer KM12 -5.30* Breast Cancer T-47D -5.24* Ovarian Cancer IGROV1 -5.23* Breast Cancer MDA-MB-231/ATCC -5.15** Colon Cancer SW-620 -5.14** Non-Small Cell Lung Cancer NCI-H322M -4.96* Colon Cancer HT29 -4.91* CNS Cancer SNB-19 -4.83* Renal Cancer CAKI-1 -4.82* Melanoma SK-MEL-28 -4.81* Non-Small Cell Lung Cancer NCI-H226 -4.75* Ovarian Cancer OVCAR-5 -4.00>* 141 National Cancer Institute Developmental Therapeutics Program Waterfall Graph LC50 NSC : D - 852077/1 Units :Molar SSPL :1D4F EXP. .. ID: 2410HT63 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Leukemia -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 CCRF-CEM HL-60(TB) K-562 MOLT-4 RPMI-8226 SR Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Non-Small Cell Lung Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 A549/ATCC EKVX HOP-62 HOP-92 NCI-H226 NCI-H23 NCI-H322M NCI-H460 NCI-H522 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Colon Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 COLO 205 HCC-2998 HCT-116 HCT-15 HT29 KM12 SW-620 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th CNS Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 SF-268 SF-295 SF-539 SNB-19 SNB-75 U251 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Melanoma -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 LOX IMVI MALME-3M M14 MDA-MB-435 SK-MEL-2 SK-MEL-28 SK-MEL-5 UACC-257 UACC-62 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Ovarian Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 IGROV1 OVCAR-3 OVCAR-4 OVCAR-5 OVCAR-8 NCI/ADR-RES SK-OV-3 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Renal Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 786-0 A498 ACHN CAKI-1 RXF 393 SN12C TK-10 UO-31 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Prostate Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 PC-3 DU-145 Log 10 of Sample Concentration ( Molar ) P er ce nt ag e G ro w th Breast Cancer -100 -50 0 50 100 -9 -8 -7 -6 -5 -4 MCF7 MDA-MB-231/ HS 578T BT-549 T-47D MDA-MB-468 144 National Cancer Institute Developmental Therapeutics Program Mean Graphs NSC : D - 852077/1 Units :Molar SSPL :1D4F EXP.

    Article Title: Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs
    Article Snippet: .. ID :2410HT63 Report Date :June 3, 2025 Test Date :October 21, 2024 Log10 High Conc :-4.0 Panel Cell Name Hollow Fiber GI50 Breast Cancer HS 578T -6.85* Leukemia MOLT-4 -6.77* Non-Small Cell Lung Cancer NCI-H522 -6.69** Breast Cancer BT-549 -6.68* Renal Cancer RXF 393 -6.63* Leukemia SR -6.62* Leukemia HL-60(TB) -6.62* Renal Cancer UO-31 -6.60* Non-Small Cell Lung Cancer A549/ATCC -6.56* Breast Cancer MCF7 -6.56* Non-Small Cell Lung Cancer NCI-H23 -6.55** CNS Cancer SF-268 -6.54* Leukemia CCRF-CEM -6.53* Melanoma SK-MEL-5 -6.48* Renal Cancer TK-10 -6.47* Renal Cancer ACHN -6.47* Renal Cancer SN12C -6.46* Non-Small Cell Lung Cancer EKVX -6.46* CNS Cancer SF-539 -6.46* Non-Small Cell Lung Cancer NCI-H460 -6.45* CNS Cancer SF-295 -6.44** Renal Cancer 786-0 -6.44* Leukemia K-562 -6.44* Colon Cancer HCT-116 -6.43* Renal Cancer CAKI-1 -6.41* Renal Cancer A498 -6.41* Prostate Cancer PC-3 -6.40* Colon Cancer HT29 -6.39* Non-Small Cell Lung Cancer HOP-62 -6.39* Melanoma MDA-MB-435 -6.38** Ovarian Cancer OVCAR-3 -6.36** Ovarian Cancer OVCAR-8 -6.30* Ovarian Cancer SK-OV-3 -6.29* Melanoma MALME-3M -6.28* Ovarian Cancer NCI/ADR-RES -6.25* Ovarian Cancer IGROV1 -6.22* CNS Cancer U251 -6.20** Melanoma SK-MEL-2 -6.09* Colon Cancer SW-620 -5.99** Non-Small Cell Lung Cancer NCI-H322M -5.97* Ovarian Cancer OVCAR-4 -5.95* Colon Cancer HCT-15 -5.94* Melanoma UACC-62 -5.92** Melanoma UACC-257 -5.90* Melanoma M14 -5.88* Breast Cancer T-47D -5.85* CNS Cancer SNB-19 -5.85* Breast Cancer MDA-MB-468 -5.73* Colon Cancer KM12 -5.71* Colon Cancer COLO 205 -5.65** Breast Cancer MDA-MB-231/ATCC -5.47** Non-Small Cell Lung Cancer NCI-H226 -5.41* Ovarian Cancer OVCAR-5 -5.35** Melanoma SK-MEL-28 -4.78* 147 National Cancer Institute Developmental Therapeutics Program Waterfall Graph TGI NSC : D - 852077/1 Units :Molar SSPL :1D4F EXP. .. ID :2410HT63 Report Date :June 3, 2025 Test Date :October 21, 2024 Log10 High Conc : -4.0 Panel Cell Name Hollow Fiber TGI Leukemia MOLT-4 -6.50* Breast Cancer HS 578T -6.45* Leukemia HL-60(TB) -6.36* Non-Small Cell Lung Cancer NCI-H522 -6.31** Breast Cancer BT-549 -6.28* Leukemia SR -6.27* Renal Cancer RXF 393 -6.27* Renal Cancer UO-31 -6.20* Non-Small Cell Lung Cancer A549/ATCC -6.12* Non-Small Cell Lung Cancer NCI-H23 -6.05** Non-Small Cell Lung Cancer EKVX -6.04* Leukemia CCRF-CEM -6.03* Melanoma SK-MEL-5 -6.02* Leukemia K-562 -6.02* Renal Cancer SN12C -5.97* Non-Small Cell Lung Cancer NCI-H460 -5.95* CNS Cancer SF-295 -5.90** CNS Cancer SF-539 -5.86* Renal Cancer ACHN -5.86* Non-Small Cell Lung Cancer HOP-62 -5.85* Renal Cancer A498 -5.85* Ovarian Cancer OVCAR-3 -5.83** Melanoma MALME-3M -5.81* Renal Cancer 786-0 -5.79* Ovarian Cancer OVCAR-8 -5.77* Melanoma MDA-MB-435 -5.70** CNS Cancer U251 -5.68** Melanoma SK-MEL-2 -5.62* Ovarian Cancer NCI/ADR-RES -5.60* Melanoma UACC-62 -5.59** Breast Cancer MCF7 -5.59* Melanoma UACC-257 -5.55* Colon Cancer HCT-15 -5.48* Ovarian Cancer IGROV1 -5.47* Ovarian Cancer OVCAR-4 -5.47* Melanoma M14 -5.43* Breast Cancer MDA-MB-468 -5.41* Non-Small Cell Lung Cancer NCI-H322M -5.38* Prostate Cancer PC-3 -5.36* Breast Cancer T-47D -5.36* Colon Cancer SW-620 -5.33** Colon Cancer COLO 205 -5.31** CNS Cancer SNB-19 -5.22* Colon Cancer HT29 -5.20* Colon Cancer KM12 -5.20* Colon Cancer HCT-116 -4.97* Ovarian Cancer SK-OV-3 -4.94* Renal Cancer CAKI-1 -4.88* Renal Cancer TK-10 -4.86* CNS Cancer SF-268 -4.80* Non-Small Cell Lung Cancer NCI-H226 -4.77* Ovarian Cancer OVCAR-5 -4.71** Melanoma SK-MEL-28 -4.45* Non-Small Cell Lung Cancer HOP-92 -4.42* Breast Cancer MDA-MB-231/ATCC -4.00>* 148 National Cancer Institute Developmental Therapeutics Program Waterfall Graph LC50 NSC : D - 852077/1 Units :Molar SSPL :1D4F EXP.

    Article Title: National Cancer Institute Developmental Therapeutics Program In-Vitro Screening Data Review Checklist
    Article Snippet: ID :0104BS79 Report Date :September 01, 2011 Test Date :April 16, 2001 Log10 High Conc : -6.0 Panel Cell Name Hollow Fiber TGI Leukemia MOLT-4 -10.00< Leukemia RPMI-8226 -10.00< CNS Cancer SF-295 -10.00<* CNS Cancer SF-539 -10.00< Melanoma SK-MEL-2 -10.00< Melanoma UACC-62 -10.00<* Ovarian Cancer IGROV1 -10.00< Renal Cancer CAKI-1 -10.00< Renal Cancer RXF 393 -10.00< Breast Cancer HS 578T -10.00< Melanoma SK-MEL-5 -9.90 Renal Cancer UO-31 -9.86 Melanoma MDA-N -9.60 Colon Cancer COLO 205 -9.59* Renal Cancer 786-0 -9.24 Non-Small Cell Lung Cancer NCI-H226 -8.97 Leukemia HL-60(TB) -8.96 Breast Cancer MCF7 -8.94 Melanoma MDA-MB-435 -8.91* Non-Small Cell Lung Cancer NCI-H460 -8.90 Melanoma LOX IMVI -8.85* Renal Cancer A498 -8.61 Ovarian Cancer SK-OV-3 -8.60 Colon Cancer SW-620 -8.42* Melanoma M14 -8.42 Melanoma MALME-3M -8.23 Leukemia CCRF-CEM -7.82 Colon Cancer HCT-116 -7.30 Colon Cancer HCT-15 -6.99 Prostate Cancer PC-3 -6.93 Non-Small Cell Lung Cancer NCI-H23 -6.90* CNS Cancer U251 -6.79* Breast Cancer MDA-MB-231/ATCC -6.79* Ovarian Cancer OVCAR-5 -6.78* CNS Cancer SNB-19 -6.60 Non-Small Cell Lung Cancer EKVX -6.58 Colon Cancer KM12 -6.49 CNS Cancer SF-268 -6.42 Non-Small Cell Lung Cancer HOP-62 -6.30 Prostate Cancer DU-145 -6.11 Colon Cancer HCC-2998 -6.06 Breast Cancer T-47D -6.05 Renal Cancer TK-10 -6.02 Non-Small Cell Lung Cancer A549/ATCC -6.00> Non-Small Cell Lung Cancer NCI-H322M -6.00> Ovarian Cancer OVCAR-3 -6.00>* Ovarian Cancer OVCAR-8 -6.00> Ovarian Cancer NCI/ADR-RES -6.00> Renal Cancer ACHN -6.00> Renal Cancer SN12C -6.00> Breast Cancer BT-549 -6.00> National Cancer Institute Developmental Therapeutics Program Waterfall Graph LC50 NSC : D - 720780/1 Units :Molar SSPL :0GZS EXP. .. ID :0104BS79 Report Date :September 01, 2011 Test Date :April 16, 2001 Log10 High Conc : -6.0 Panel Cell Name Hollow Fiber LC50 Melanoma UACC-62 -10.00<* Breast Cancer HS 578T -9.31 Melanoma SK-MEL-5 -9.14 Colon Cancer COLO 205 -9.04* CNS Cancer SF-295 -8.84* CNS Cancer SF-539 -8.47 Melanoma MDA-N -8.37 Renal Cancer A498 -7.25 Melanoma M14 -7.00 Renal Cancer UO-31 -6.78 Colon Cancer SW-620 -6.68* Breast Cancer MCF7 -6.61 Renal Cancer 786-0 -6.40 Colon Cancer HCT-116 -6.35 Colon Cancer HCT-15 -6.35 Melanoma SK-MEL-2 -6.21 Ovarian Cancer IGROV1 -6.21 Non-Small Cell Lung Cancer NCI-H23 -6.16* Melanoma MDA-MB-435 -6.13* Renal Cancer CAKI-1 -6.09 Leukemia MOLT-4 -6.03 Leukemia CCRF-CEM -6.00> Leukemia HL-60(TB) -6.00> Leukemia K-562 -6.00> Leukemia RPMI-8226 -6.00> Non-Small Cell Lung Cancer A549/ATCC -6.00> Non-Small Cell Lung Cancer EKVX -6.00> Non-Small Cell Lung Cancer HOP-62 -6.00> Non-Small Cell Lung Cancer NCI-H226 -6.00> Non-Small Cell Lung Cancer NCI-H322M -6.00> Non-Small Cell Lung Cancer NCI-H460 -6.00> Colon Cancer HCC-2998 -6.00> Colon Cancer KM12 -6.00> CNS Cancer SF-268 -6.00> CNS Cancer SNB-19 -6.00> CNS Cancer U251 -6.00>* Melanoma LOX IMVI -6.00>* Melanoma MALME-3M -6.00> Ovarian Cancer OVCAR-3 -6.00>* Ovarian Cancer OVCAR-5 -6.00>* Ovarian Cancer OVCAR-8 -6.00> Ovarian Cancer NCI/ADR-RES -6.00> Ovarian Cancer SK-OV-3 -6.00> Renal Cancer ACHN -6.00> Renal Cancer SN12C -6.00> Renal Cancer TK-10 -6.00> Prostate Cancer PC-3 -6.00> Prostate Cancer DU-145 -6.00> Breast Cancer MDA-MB-231/ATCC -6.00>* Breast Cancer BT-549 -6.00> Breast Cancer T-47D -6.00> .. ID :0104BS79 Report Date :September 01, 2011 Test Date :April 16, 2001 Log10 High Conc : -6.0 Panel Cell Name Hollow Fiber LC50 Melanoma UACC-62 -10.00<* Breast Cancer HS 578T -9.31 Melanoma SK-MEL-5 -9.14 Colon Cancer COLO 205 -9.04* CNS Cancer SF-295 -8.84* CNS Cancer SF-539 -8.47 Melanoma MDA-N -8.37 Renal Cancer A498 -7.25 Melanoma M14 -7.00 Renal Cancer UO-31 -6.78 Colon Cancer SW-620 -6.68* Breast Cancer MCF7 -6.61 Renal Cancer 786-0 -6.40 Colon Cancer HCT-116 -6.35 Colon Cancer HCT-15 -6.35 Melanoma SK-MEL-2 -6.21 Ovarian Cancer IGROV1 -6.21 Non-Small Cell Lung Cancer NCI-H23 -6.16* Melanoma MDA-MB-435 -6.13* Renal Cancer CAKI-1 -6.09 Leukemia MOLT-4 -6.03 Leukemia CCRF-CEM -6.00> Leukemia HL-60(TB) -6.00> Leukemia K-562 -6.00> Leukemia RPMI-8226 -6.00> Non-Small Cell Lung Cancer A549/ATCC -6.00> Non-Small Cell Lung Cancer EKVX -6.00> Non-Small Cell Lung Cancer HOP-62 -6.00> Non-Small Cell Lung Cancer NCI-H226 -6.00> Non-Small Cell Lung Cancer NCI-H322M -6.00> Non-Small Cell Lung Cancer NCI-H460 -6.00> Colon Cancer HCC-2998 -6.00> Colon Cancer KM12 -6.00> CNS Cancer SF-268 -6.00> CNS Cancer SNB-19 -6.00> CNS Cancer U251 -6.00>* Melanoma LOX IMVI -6.00>* Melanoma MALME-3M -6.00> Ovarian Cancer OVCAR-3 -6.00>* Ovarian Cancer OVCAR-5 -6.00>* Ovarian Cancer OVCAR-8 -6.00> Ovarian Cancer NCI/ADR-RES -6.00> Ovarian Cancer SK-OV-3 -6.00> Renal Cancer ACHN -6.00> Renal Cancer SN12C -6.00> Renal Cancer TK-10 -6.00> Prostate Cancer PC-3 -6.00> Prostate Cancer DU-145 -6.00> Breast Cancer MDA-MB-231/ATCC -6.00>* Breast Cancer BT-549 -6.00> Breast Cancer T-47D -6.00>

    Article Title: Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs
    Article Snippet: ID :2405HT49 Report Date :June 5, 2025 Test Date :May 6, 2024 Log10 High Conc :-4.0 Panel Cell Name Hollow Fiber GI50 CNS Cancer SF-539 -6.74* Non-Small Cell Lung Cancer NCI-H522 -6.73** Leukemia MOLT-4 -6.72* Breast Cancer HS 578T -6.71* Leukemia HL-60(TB) -6.64* Non-Small Cell Lung Cancer EKVX -6.64* Leukemia SR -6.61* Breast Cancer BT-549 -6.58* CNS Cancer SF-268 -6.57* Renal Cancer SN12C -6.55* Renal Cancer UO-31 -6.53* Renal Cancer TK-10 -6.52* Melanoma SK-MEL-5 -6.50* Non-Small Cell Lung Cancer A549/ATCC -6.47* CNS Cancer SF-295 -6.44** CNS Cancer SNB-75 -6.44* Non-Small Cell Lung Cancer NCI-H460 -6.44* Non-Small Cell Lung Cancer HOP-62 -6.43* Prostate Cancer DU-145 -6.42* Non-Small Cell Lung Cancer NCI-H23 -6.42** Renal Cancer ACHN -6.41* Renal Cancer 786-0 -6.41* Colon Cancer HCT-116 -6.40* Renal Cancer A498 -6.37* Renal Cancer CAKI-1 -6.36* Leukemia K-562 -6.35* Leukemia CCRF-CEM -6.31* Ovarian Cancer OVCAR-3 -6.29** Prostate Cancer PC-3 -6.27* Ovarian Cancer NCI/ADR-RES -6.26* Breast Cancer MCF7 -6.25* Colon Cancer SW-620 -6.21** Colon Cancer HT29 -6.20* Melanoma LOX IMVI -6.16** Melanoma MALME-3M -6.05* Melanoma M14 -6.05* Ovarian Cancer OVCAR-4 -6.00* Ovarian Cancer OVCAR-8 -5.98* Melanoma MDA-MB-435 -5.97** Colon Cancer HCT-15 -5.97* Melanoma SK-MEL-2 -5.95* CNS Cancer U251 -5.95** Ovarian Cancer SK-OV-3 -5.92* Melanoma UACC-62 -5.87** Leukemia RPMI-8226 -5.85* Colon Cancer HCC-2998 -5.81* Melanoma UACC-257 -5.78* CNS Cancer SNB-19 -5.78* Breast Cancer MDA-MB-468 -5.72* Colon Cancer COLO 205 -5.68** Non-Small Cell Lung Cancer NCI-H322M -5.65* Colon Cancer KM12 -5.64* Ovarian Cancer IGROV1 -5.64* Melanoma SK-MEL-28 -5.63* Breast Cancer T-47D -5.62* Breast Cancer MDA-MB-231/ATCC -5.56** Non-Small Cell Lung Cancer NCI-H226 -5.50* Ovarian Cancer OVCAR-5 -4.72** 168 National Cancer Institute Developmental Therapeutics Program Waterfall Graph TGI NSC : D - 852078/1 Units :Molar SSPL :1D4F EXP. .. ID :2405HT49 Report Date :June 5, 2025 Test Date :May 6, 2024 Log10 High Conc : -4.0 Panel Cell Name Hollow Fiber TGI Leukemia MOLT-4 -6.46* Leukemia HL-60(TB) -6.34* Non-Small Cell Lung Cancer NCI-H522 -6.31** Leukemia SR -6.25* Non-Small Cell Lung Cancer EKVX -6.15* Breast Cancer HS 578T -6.15* Breast Cancer BT-549 -6.13* Renal Cancer TK-10 -6.09* Renal Cancer UO-31 -6.09* Melanoma SK-MEL-5 -5.98* Non-Small Cell Lung Cancer NCI-H460 -5.95* Renal Cancer SN12C -5.92* Non-Small Cell Lung Cancer HOP-62 -5.92* CNS Cancer SF-539 -5.92* CNS Cancer SF-295 -5.87** Non-Small Cell Lung Cancer NCI-H23 -5.85** CNS Cancer SNB-75 -5.85* Leukemia CCRF-CEM -5.83* Non-Small Cell Lung Cancer A549/ATCC -5.83* Renal Cancer ACHN -5.82* Renal Cancer A498 -5.81* Leukemia K-562 -5.81* Renal Cancer 786-0 -5.79* Ovarian Cancer OVCAR-3 -5.72** Melanoma LOX IMVI -5.67** Melanoma MALME-3M -5.67* Ovarian Cancer NCI/ADR-RES -5.67* Ovarian Cancer OVCAR-8 -5.64* CNS Cancer U251 -5.61** Colon Cancer HCT-116 -5.60* Melanoma M14 -5.59* Breast Cancer MCF7 -5.58* Melanoma UACC-62 -5.57** Melanoma SK-MEL-2 -5.57* Leukemia RPMI-8226 -5.54* Colon Cancer HCT-15 -5.52* Melanoma MDA-MB-435 -5.51** Ovarian Cancer OVCAR-4 -5.51* Melanoma UACC-257 -5.47* Prostate Cancer PC-3 -5.44* Colon Cancer SW-620 -5.41** Colon Cancer HCC-2998 -5.41* Ovarian Cancer SK-OV-3 -5.38* Colon Cancer HT29 -5.36* Breast Cancer MDA-MB-468 -5.36* Colon Cancer COLO 205 -5.33** Colon Cancer KM12 -5.24* Ovarian Cancer IGROV1 -5.21* Breast Cancer T-47D -5.21* Breast Cancer MDA-MB-231/ATCC -5.21** Melanoma SK-MEL-28 -5.11* Non-Small Cell Lung Cancer NCI-H226 -5.02* CNS Cancer SNB-19 -4.98* Renal Cancer CAKI-1 -4.93* Non-Small Cell Lung Cancer NCI-H322M -4.84* Non-Small Cell Lung Cancer HOP-92 -4.63* Prostate Cancer DU-145 -4.54* Ovarian Cancer OVCAR-5 -4.00>* 169 National Cancer Institute Developmental Therapeutics Program Waterfall Graph LC50 NSC : D - 852078/1 Units :Molar SSPL :1D4F EXP. .. > 1.00E-4 Breast Cancer MCF7 1.606 10.698 9.467 10.845 4.622 1.924 0.266 87 102 33 -3 -83 * 5.70E-7 * 8.18E-6 * 3.83E-5 MDA-MB-231/ATCC 5.359 16.731 16.721 16.960 15.722 4.766 4.449 100 102 91 -11 -17 * 2.53E-6 * 7.80E-6 > 1.00E-4 HS 578T 2.533 4.461 4.027 3.838 1.552 0.878 0.056 78 69 -39 -65 -98 * 1.50E-7 * 4.36E-7 * 2.65E-6 BT-549 6.214 14.693 13.505 14.402 4.400 0.884 0.061 86 97 -29 -86 -99 * 2.35E-7 * 5.86E-7 * 2.33E-6 T-47D 5.553 10.427 9.937 10.245 10.114 3.970 3.152 90 96 94 -28 -43 * 2.28E-6 * 5.84E-6 > 1.00E-4 MDA-MB-468 7.702 9.418 9.099 9.720 9.473 3.971 2.159 81 118 103 -48 -72 * 2.24E-6 * 4.79E-6 * 1.17E-5 Compound 13d 171 National Cancer Institute Developmental Therapeutics Program Dose Response Curves NSC: D - 852078 / 1 Report Date: June 5, 2025 SSPL: 1D4F Test Date: October 21, 2024 EXP.

    Article Title: Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs
    Article Snippet: ID :2410HT63 Report Date :June 5, 2025 Test Date :October 21, 2024 Log10 High Conc :-4.0 Panel Cell Name Hollow Fiber GI50 Breast Cancer HS 578T -6.83* Leukemia MOLT-4 -6.72* Non-Small Cell Lung Cancer NCI-H522 -6.68** Renal Cancer RXF 393 -6.66* Breast Cancer BT-549 -6.63* Leukemia SR -6.56* Renal Cancer UO-31 -6.54* CNS Cancer SF-268 -6.54* Prostate Cancer DU-145 -6.49* Non-Small Cell Lung Cancer NCI-H23 -6.49** Leukemia HL-60(TB) -6.48* Renal Cancer SN12C -6.47* Colon Cancer HCT-116 -6.46* Non-Small Cell Lung Cancer EKVX -6.46* Renal Cancer ACHN -6.46* Renal Cancer 786-0 -6.46* Renal Cancer TK-10 -6.46* Melanoma SK-MEL-5 -6.44* Non-Small Cell Lung Cancer NCI-H460 -6.44* Leukemia CCRF-CEM -6.43* Non-Small Cell Lung Cancer A549/ATCC -6.43* CNS Cancer SF-295 -6.41** CNS Cancer SF-539 -6.40* Renal Cancer A498 -6.39* Leukemia K-562 -6.38* Non-Small Cell Lung Cancer HOP-62 -6.38* Prostate Cancer PC-3 -6.37* Renal Cancer CAKI-1 -6.36* Ovarian Cancer OVCAR-3 -6.31** Colon Cancer HT29 -6.26* Breast Cancer MCF7 -6.24* Ovarian Cancer NCI/ADR-RES -6.23* Melanoma MALME-3M -6.23* Ovarian Cancer OVCAR-8 -6.19* Melanoma MDA-MB-435 -6.17** Ovarian Cancer SK-OV-3 -6.16* CNS Cancer U251 -6.08** Ovarian Cancer IGROV1 -5.97* Colon Cancer HCT-15 -5.94* Melanoma UACC-257 -5.92* Colon Cancer SW-620 -5.90** Melanoma SK-MEL-2 -5.90* Ovarian Cancer OVCAR-4 -5.89* Non-Small Cell Lung Cancer NCI-H322M -5.88* Non-Small Cell Lung Cancer NCI-H226 -5.86* Melanoma M14 -5.85* CNS Cancer SNB-19 -5.84* Melanoma UACC-62 -5.82** Colon Cancer KM12 -5.69* Breast Cancer MDA-MB-468 -5.65* Breast Cancer T-47D -5.64* Breast Cancer MDA-MB-231/ATCC -5.60** Colon Cancer COLO 205 -5.56** Melanoma SK-MEL-28 -5.53* Ovarian Cancer OVCAR-5 -5.37** 175 National Cancer Institute Developmental Therapeutics Program Waterfall Graph TGI NSC : D - 852078/1 Units :Molar SSPL :1D4F EXP. .. ID :2410HT63 Report Date :June 5, 2025 Test Date :October 21, 2024 Log10 High Conc : -4.0 Panel Cell Name Hollow Fiber TGI Leukemia MOLT-4 -6.47* Breast Cancer HS 578T -6.36* Non-Small Cell Lung Cancer NCI-H522 -6.30** Renal Cancer RXF 393 -6.28* Breast Cancer BT-549 -6.23* Renal Cancer UO-31 -6.13* Leukemia SR -6.13* Leukemia HL-60(TB) -6.10* Non-Small Cell Lung Cancer EKVX -6.04* CNS Cancer SF-268 -6.03* Melanoma SK-MEL-5 -5.99* Non-Small Cell Lung Cancer NCI-H460 -5.93* Non-Small Cell Lung Cancer A549/ATCC -5.91* Leukemia CCRF-CEM -5.91* Non-Small Cell Lung Cancer NCI-H23 -5.90** Renal Cancer SN12C -5.90* Renal Cancer 786-0 -5.89* CNS Cancer SF-295 -5.89** Leukemia K-562 -5.87* Non-Small Cell Lung Cancer HOP-62 -5.87* Renal Cancer ACHN -5.87* CNS Cancer SF-539 -5.87* Renal Cancer A498 -5.84* Ovarian Cancer OVCAR-3 -5.75** Melanoma MALME-3M -5.73* Ovarian Cancer OVCAR-8 -5.70* CNS Cancer U251 -5.64** Ovarian Cancer NCI/ADR-RES -5.63* Renal Cancer TK-10 -5.62* Colon Cancer HCT-116 -5.61* Melanoma MDA-MB-435 -5.60** Colon Cancer HT29 -5.59* Melanoma UACC-257 -5.56* Melanoma SK-MEL-2 -5.54* Melanoma UACC-62 -5.53** Prostate Cancer PC-3 -5.50* Melanoma M14 -5.49* Ovarian Cancer OVCAR-4 -5.46* Ovarian Cancer IGROV1 -5.41* Non-Small Cell Lung Cancer NCI-H226 -5.40* Colon Cancer HCT-15 -5.37* CNS Cancer SNB-19 -5.36* Ovarian Cancer SK-OV-3 -5.34* Non-Small Cell Lung Cancer NCI-H322M -5.34* Breast Cancer MDA-MB-468 -5.32* Renal Cancer CAKI-1 -5.29* Colon Cancer KM12 -5.27* Colon Cancer COLO 205 -5.25** Breast Cancer T-47D -5.23* Colon Cancer SW-620 -5.19** Breast Cancer MDA-MB-231/ATCC -5.11** Breast Cancer MCF7 -5.09* Melanoma SK-MEL-28 -4.91* Ovarian Cancer OVCAR-5 -4.74** Non-Small Cell Lung Cancer HOP-92 -4.52* 176 National Cancer Institute Developmental Therapeutics Program Waterfall Graph LC50 NSC : D - 852078/1 Units :Molar SSPL :1D4F EXP. .. CAKI-1 1.194 5.150 4.789 4.839 2.184 0.770 0.648 91 92 25 -36 -46 * 4.25E-7 * 2.59E-6 > 1.00E-4 RXF 393 2.364 . . . . . . . . . . . . . . SN12C 1.357 4.472 4.086 4.176 1.705 0.877 0.280 88 90 11 -35 -79 * 3.24E-7 * 1.74E-6 * 2.15E-5 TK-10 7.325 15.429 15.813 15.410 7.500 8.975 1.479 105 100 2 20 -80 * 3.23E-7 * 1.60E-5 * 5.04E-5 UO-31 1.566 4.974 4.984 4.974 2.186 0.016 0.033 100 100 18 -99 -98 * 4.08E-7 * 1.43E-6 * 3.82E-6 Prostate Cancer PC-3 4.573 18.261 20.127 18.893 11.186 2.804 0.559 114 105 48 -39 -88 * 9.35E-7 * 3.59E-6 * 1.70E-5 DU-145 1.298 4.191 4.336 4.240 1.697 0.799 0.720 105 102 14 -38 -44 * 3.87E-7 * 1.84E-6 > 1.00E-4 Breast Cancer MCF7 2.355 13.891 11.806 13.904 6.086 1.842 0.176 82 100 32 -22 -92 * 5.48E-7 * 3.96E-6 * 2.51E-5 MDA-MB-231/ATCC 5.369 10.800 11.373 11.549 10.939 4.075 0.564 111 114 103 -24 -90 * 2.60E-6 * 6.45E-6 * 2.49E-5 HS 578T 1.822 3.949 3.562 3.535 1.795 0.848 0.032 82 80 -1 -54 -98 * 2.36E-7 * 9.60E-7 * 8.58E-6 BT-549 6.607 14.246 14.276 13.842 7.991 2.045 0.025 100 95 18 -69 -100 * 3.85E-7 * 1.62E-6 * 6.05E-6 T-47D 4.991 12.528 11.644 11.724 12.247 3.729 3.432 88 90 97 -25 -31 * 2.41E-6 * 6.20E-6 > 1.00E-4 MDA-MB-468 7.624 8.936 8.586 9.191 6.901 4.342 1.779 75 119 -9 -43 -77 * 3.44E-7 * 8.44E-7 * 1.61E-5 Compound 13e 178 National Cancer Institute Developmental Therapeutics Program Dose Response Curves NSC: D - 852079 / 1 Report Date: January 14, 2025 SSPL: 1D4F Test Date: May 6, 2024 EXP.

    Article Title: Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs
    Article Snippet: .. ID :2410HT63 Report Date :June 5, 2025 Test Date :October 21, 2024 Log10 High Conc :-4.0 Panel Cell Name Hollow Fiber GI50 Leukemia MOLT-4 -6.75* Breast Cancer HS 578T -6.74* Non-Small Cell Lung Cancer NCI-H522 -6.64** Renal Cancer RXF 393 -6.59* Breast Cancer BT-549 -6.57* Renal Cancer SN12C -6.56* CNS Cancer SF-268 -6.50* CNS Cancer SF-539 -6.46* Renal Cancer UO-31 -6.46* Non-Small Cell Lung Cancer A549/ATCC -6.44* Non-Small Cell Lung Cancer NCI-H23 -6.43** Renal Cancer ACHN -6.41* Prostate Cancer DU-145 -6.39* Leukemia CCRF-CEM -6.38* Colon Cancer HCT-116 -6.37* Leukemia SR -6.36* Non-Small Cell Lung Cancer NCI-H460 -6.36* Renal Cancer TK-10 -6.34* Melanoma SK-MEL-5 -6.31* CNS Cancer SF-295 -6.31** Non-Small Cell Lung Cancer HOP-62 -6.30* Breast Cancer MCF7 -6.28* Renal Cancer A498 -6.28* Non-Small Cell Lung Cancer EKVX -6.26* Renal Cancer 786-0 -6.20* Prostate Cancer PC-3 -6.18* Leukemia HL-60(TB) -6.17* Leukemia K-562 -6.15* Ovarian Cancer OVCAR-3 -6.11** Melanoma MDA-MB-435 -5.98** Ovarian Cancer OVCAR-8 -5.92* Colon Cancer HT29 -5.92* Renal Cancer CAKI-1 -5.89* Ovarian Cancer NCI/ADR-RES -5.87* CNS Cancer U251 -5.84** Melanoma SK-MEL-2 -5.81* Melanoma MALME-3M -5.80* Melanoma UACC-257 -5.78* Ovarian Cancer OVCAR-4 -5.77* Ovarian Cancer IGROV1 -5.77* Melanoma M14 -5.76* Melanoma UACC-62 -5.76** Colon Cancer KM12 -5.76* Non-Small Cell Lung Cancer NCI-H322M -5.75* Ovarian Cancer SK-OV-3 -5.73* Melanoma SK-MEL-28 -5.71* Colon Cancer SW-620 -5.68** Colon Cancer HCT-15 -5.66* Non-Small Cell Lung Cancer NCI-H226 -5.63* Breast Cancer T-47D -5.62* CNS Cancer SNB-19 -5.61* Breast Cancer MDA-MB-468 -5.61* Colon Cancer COLO 205 -5.59** Breast Cancer MDA-MB-231/ATCC -5.53** Ovarian Cancer OVCAR-5 -5.41** Non-Small Cell Lung Cancer HOP-92 -4.68* 203 National Cancer Institute Developmental Therapeutics Program Waterfall Graph TGI NSC : D - 852080/1 Units :Molar SSPL :1D4F EXP. .. ID :2410HT63 Report Date :June 5, 2025 Test Date :October 21, 2024 Log10 High Conc : -4.0 Panel Cell Name Hollow Fiber TGI Leukemia MOLT-4 -6.47* Breast Cancer HS 578T -6.30* Non-Small Cell Lung Cancer NCI-H522 -6.25** Renal Cancer RXF 393 -6.14* Breast Cancer BT-549 -6.12* Renal Cancer UO-31 -5.95* Non-Small Cell Lung Cancer A549/ATCC -5.88* Non-Small Cell Lung Cancer NCI-H460 -5.88* Leukemia SR -5.82* Leukemia CCRF-CEM -5.82* CNS Cancer SF-539 -5.81* Non-Small Cell Lung Cancer NCI-H23 -5.78** CNS Cancer SF-295 -5.78** Renal Cancer ACHN -5.78* Non-Small Cell Lung Cancer HOP-62 -5.76* Renal Cancer SN12C -5.73* Melanoma SK-MEL-5 -5.72* Leukemia HL-60(TB) -5.72* Leukemia K-562 -5.70* Renal Cancer A498 -5.66* Non-Small Cell Lung Cancer EKVX -5.62* Ovarian Cancer OVCAR-3 -5.61** Melanoma MALME-3M -5.51* Ovarian Cancer OVCAR-8 -5.50* CNS Cancer U251 -5.49** Melanoma UACC-62 -5.49** Melanoma SK-MEL-2 -5.48* Renal Cancer 786-0 -5.47* Melanoma UACC-257 -5.46* Ovarian Cancer NCI/ADR-RES -5.45* Melanoma MDA-MB-435 -5.44** Melanoma M14 -5.42* Colon Cancer HT29 -5.41* Ovarian Cancer OVCAR-4 -5.37* Ovarian Cancer IGROV1 -5.35* Colon Cancer HCT-116 -5.34* Breast Cancer MCF7 -5.32* Non-Small Cell Lung Cancer NCI-H322M -5.31* Breast Cancer MDA-MB-468 -5.29* Breast Cancer T-47D -5.23* Non-Small Cell Lung Cancer NCI-H226 -5.22* Colon Cancer KM12 -5.21* Colon Cancer COLO 205 -5.21** Prostate Cancer PC-3 -5.16* CNS Cancer SNB-19 -5.16* Melanoma SK-MEL-28 -5.11* Colon Cancer SW-620 -5.09** Colon Cancer HCT-15 -5.07* Ovarian Cancer SK-OV-3 -4.99* Renal Cancer CAKI-1 -4.88* Ovarian Cancer OVCAR-5 -4.80** Renal Cancer TK-10 -4.79* CNS Cancer SF-268 -4.72* Prostate Cancer DU-145 -4.51* Non-Small Cell Lung Cancer HOP-92 -4.43* 204 National Cancer Institute Developmental Therapeutics Program Waterfall Graph LC50 NSC : D - 852080/1 Units :Molar SSPL :1D4F EXP.

    other:

    Article Title: Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs
    Article Snippet: Melanoma UACC-62 -4.11** Renal Cancer ACHN -4.09* Non-Small Cell Lung Cancer A549/ATCC -4.00> Non-Small Cell Lung Cancer EKVX -4.00> Non-Small Cell Lung Cancer HOP-62 -4.00> Non-Small Cell Lung Cancer HOP-92 -4.00> Non-Small Cell Lung Cancer NCI-H23 -4.00>* Non-Small Cell Lung Cancer NCI-H322M -4.00> Colon Cancer COLO 205 -4.00>* Colon Cancer HCT-116 -4.00>



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